Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1.

ABSTRACT: EHMT2 is a histone lysine methyltransferase localized in euchromatin regions and acting as a corepressor for specific transcription factors. Although the role of EHMT2 in transcriptional regulation has been well documented, the pathologic consequences of its dysfunction in human disease have not been well understood. Here, we describe important roles of EHMT2 in human carcinogenesis. Expression levels of EHMT2 are significantly elevated in human bladder carcinomas compared with nonneoplastic bladder tissues (P < .0001) in real-time polymerase chain reaction analysis. Complementary DNA microarray analysis also revealed its overexpression in various types of cancer. The reduction of EHMT2 expression by small interfering RNAs resulted in the suppression of the growth of cancer cells and possi

SUBMITTER: Cho HS 

PROVIDER: S-EPMC3156658 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature