Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome.

ABSTRACT:

Background

Our objective was to find single nucleotide polymorphisms (SNPs), within transcriptional pathways of glucose and lipid metabolism, which are related to multiple features of the metabolic syndrome (MetS).

Methods

373 SNPs were measured in 3575 subjects of the Doetinchem cohort. Prevalence of MetS features, i.e. hyperglycemia, abdominal obesity, decreased HDL-cholesterol levels and hypertension, were measured twice in 6 years. Associations between the SNPs and the individual MetS features were analyzed by log-linear models. For SNPs related to multiple MetS features (P < 0.01), we investigated whether these associations were independent of each other.

Results

Two SNPs, CETP Ile405Val and APOE Cys112Arg, were associated with both the prevalence of low HDL-chol

SUBMITTER: Povel CM 

PROVIDER: S-EPMC3156750 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature