Hox10 genes function in kidney development in the differentiation and integration of the cortical stroma.

ABSTRACT: Organogenesis requires the differentiation and integration of distinct populations of cells to form a functional organ. In the kidney, reciprocal interactions between the ureter and the nephrogenic mesenchyme are required for organ formation. Additionally, the differentiation and integration of stromal cells are also necessary for the proper development of this organ. Much remains to be understood regarding the origin of cortical stromal cells and the pathways involved in their formation and function. By generating triple mutants in the Hox10 paralogous group genes, we demonstrate that Hox10 genes play a critical role in the developing kidney. Careful examination of control kidneys show that Foxd1-expressing stromal precursor cells are first observed in a cap-like pattern anterior to the m

SUBMITTER: Yallowitz AR 

PROVIDER: S-EPMC3156768 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature