Preventing progression of cardiac hypertrophy and development of heart failure by paricalcitol therapy in rats.

ABSTRACT:

Aims

Vitamin D deficiency is associated with cardiac hypertrophy and heart failure, and vitamin D therapy prevents the progression of cardiac hypertrophy in animal models. Here, we examine whether vitamin D therapy prevents progression of pre-existing cardiac hypertrophy and development of heart failure.

Methods and results

When male Dahl salt-sensitive rats were fed a high salt (HS) diet, all rats developed cardiac hypertrophy after 5 weeks. Thereafter, rats were treated with vehicle (V), paricalcitol (PC, an active vitamin D analogue, at 200 ng, IP 3x/week), enalapril (EP, 90 μg/day), and PC + EP. All groups were continued on the HS diet and evaluated after 4 weeks of therapy. The PC and PC + EP groups, but not the V and EP only groups, showed significant prevention of pro

SUBMITTER: Bae S 

PROVIDER: S-EPMC3156906 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature