Ontology highlight
ABSTRACT:
SUBMITTER: Haffner MC
PROVIDER: S-EPMC3157086 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Nature genetics 20100704 8
DNA double-strand breaks (DSBs) can lead to the development of genomic rearrangements, which are hallmarks of cancer. Fusions between TMPRSS2, encoding the transmembrane serine protease isoform 2, and ERG, encoding the v-ets erythroblastosis virus E26 oncogene homolog, are among the most common oncogenic rearrangements observed in human cancer. We show that androgen signaling promotes co-recruitment of androgen receptor and topoisomerase II beta (TOP2B) to sites of TMPRSS2-ERG genomic breakpoint ...[more]