Cell cycle regulation and cytoskeletal remodelling are critical processes in the nutritional programming of embryonic development.

ABSTRACT: Many mechanisms purport to explain how nutritional signals during early development are manifested as disease in the adult offspring. While these describe processes leading from nutritional insult to development of the actual pathology, the initial underlying cause of the programming effect remains elusive. To establish the primary drivers of programming, this study aimed to capture embryonic gene and protein changes in the whole embryo at the time of nutritional insult rather than downstream phenotypic effects. By using a cross-over design of two well established models of maternal protein and iron restriction we aimed to identify putative common "gatekeepers" which may drive nutritional programming.Both protein and iron deficiency in utero reduced the nephron complement in adult male Wis

SUBMITTER: Swali A 

PROVIDER: S-EPMC3157362 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature