Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma.

ABSTRACT:

Background

Malignant mesothelioma (MM) is a rare, highly aggressive tumor, associated to asbestos exposure. To date no chemotherapy regimen for MM has proven to be definitively curative, and new therapies for MM treatment need to be developed. We have previously shown in vivo that piroxicam/cisplatin combined treatment in MM, specifically acts on cell cycle regulation triggering apoptosis, with survival increase.

Methodology/principal findings

We analyzed, at molecular level, the apoptotic increase caused by piroxicam/cisplatin treatment in MM cell lines. By means of genome wide analyses, we analyzed transcriptional gene deregulation both after the single piroxicam or cisplatin and the combined treatment. Here we show that apoptotic increase following combined treatment is m

SUBMITTER: Baldi A 

PROVIDER: S-EPMC3157425 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature