Ploidy influences cellular responses to gross chromosomal rearrangements in Saccharomyces cerevisiae.

ABSTRACT:

Background

Gross chromosomal rearrangements (GCRs) such as aneuploidy are key factors in genome evolution as well as being common features of human cancer. Their role in tumour initiation and progression has not yet been completely elucidated and the effects of additional chromosomes in cancer cells are still unknown. Most previous studies in which Saccharomyces cerevisiae has been used as a model for cancer cells have been carried out in the haploid context. To obtain new insights on the role of ploidy, the cellular effects of GCRs were compared between the haploid and diploid contexts.

Results

A total number of 21 haploid and diploid S. cerevisiae strains carrying various types of GCRs (aneuploidies, nonreciprocal translocations, segmental duplications and deletions) were

SUBMITTER: Jung PP 

PROVIDER: S-EPMC3157476 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature