Directed heterodimerization: stereocontrolled assembly via solvent-caged unsymmetrical diazene fragmentation.

ABSTRACT: A general strategy for the directed and stereocontrolled assembly of carbon-carbon linked heterodimeric hexahydropyrroloindoles is described. The stepwise union of complex amines in the form of mixed diazenes followed by photoexpulsion of dinitrogen in a solvent cage provides completely guided assembly at challenging C(sp(3))-C(sp(3)) and C(sp(3))-C(sp(2)) connections.

SUBMITTER: Movassaghi M 

PROVIDER: S-EPMC3157567 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature