Annotation concept synthesis and enrichment analysis: a logic-based approach to the interpretation of high-throughput experiments.

ABSTRACT:

Motivation

Annotation Enrichment Analysis (AEA) is a widely used analytical approach to process data generated by high-throughput genomic and proteomic experiments such as gene expression microarrays. The analysis uncovers and summarizes discriminating background information (e.g. GO annotations) for sets of genes identified by experiments (e.g. a set of differentially expressed genes, a cluster). The discovered information is utilized by human experts to find biological interpretations of the experiments. However, AEA isolates and tests for overrepresentation only individual annotation terms or groups of similar terms and is limited in its ability to uncover complex phenomena involving relationship between multiple annotation terms from various knowledge bases. Also, AEA assumes t

SUBMITTER: Jiline M 

PROVIDER: S-EPMC3157920 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature