Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation.

ABSTRACT: Patients with chronic obstructive pulmonary disease (COPD) exhibit dominant features of chronic bronchitis, emphysema, and/or asthma, with a common phenotype of airflow obstruction. COPD pulmonary physiology reflects the sum of pathological changes in COPD, which can occur in large central airways, small peripheral airways, and the lung parenchyma. Quantitative or high-resolution computed tomography is used as a surrogate measure for assessment of disease progression. Different biological or molecular markers have been reported that reflect the mechanistic or pathogenic triad of inflammation, proteases, and oxidants and correspond to the different aspects of COPD histopathology. Similar to the pathogenic triad markers, genetic variations or polymorphisms have also been linked to COPD-assoc

SUBMITTER: Fischer BM 

PROVIDER: S-EPMC3157944 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature