Intramolecular Cyclization Strategies Toward the Synthesis of Zoanthamine Alkaloids.

ABSTRACT: Stabilized 2-amino-1,3-dienes can participate in intramolecular Diels-Alder (IMDA) reactions with pendant dienophiles. We found that these dienes can be readily prepared via standard palladium-mediated coupling reactions and have comparable reactivity to 2-oxodienes. Application of these substrates to the synthesis of tetracyclic model systems representing the ABCE motif of the zoanthamines is presented.

SUBMITTER: Fischer D 

PROVIDER: S-EPMC3157960 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature