Neurodegenerative properties of chronic pain: cognitive decline in patients with chronic pancreatitis.

ABSTRACT: Chronic pain has been associated with impaired cognitive function. We examined cognitive performance in patients with severe chronic pancreatitis pain. We explored the following factors for their contribution to observed cognitive deficits: pain duration, comorbidity (depression, sleep disturbance), use of opioids, and premorbid alcohol abuse. The cognitive profiles of 16 patients with severe pain due to chronic pancreatitis were determined using an extensive neuropsychological test battery. Data from three cognitive domains (psychomotor performance, memory, executive functions) were compared to data from healthy controls matched for age, gender and education. Multivariate multilevel analysis of the data showed decreased test scores in patients with chronic pancreatitis pain in different c

SUBMITTER: Jongsma ML 

PROVIDER: S-EPMC3158076 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature