FGF-2 deficiency does not influence FGF ligand and receptor expression during development of the nigrostriatal system.

ABSTRACT: Secreted proteins of the fibroblast growth factor (FGF) family play important roles during development of various organ systems. A detailed knowledge of their temporal and spatial expression profiles, especially of closely related FGF family members, are essential to further identification of specific functions in distinct tissues. In the central nervous system dopaminergic neurons of the substantia nigra and their axonal projections into the striatum progressively degenerate in Parkinson's disease. In contrast, FGF-2 deficient mice display increased numbers of dopaminergic neurons. In this study, we determined the expression profiles of all 22 FGF-ligands and 10 FGF-receptor isoforms, in order to clarify, if FGF-2 deficiency leads to compensatory up-regulation of other FGFs in the nigrost

SUBMITTER: Ratzka A 

PROVIDER: S-EPMC3158085 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature