Statin use following intracerebral hemorrhage: a decision analysis.

ABSTRACT:

Context

Statins are widely prescribed for primary and secondary prevention of ischemic cardiac and cerebrovascular disease. Although serious adverse effects are uncommon, results from a recent clinical trial suggested increased risk of intracerebral hemorrhage (ICH) associated with statin use. For patients with baseline elevated risk of ICH, it is not known whether this potential adverse effect offsets the cardiovascular and cerebrovascular benefits.

Objective

To address the following clinical question: Given a history of prior ICH, should statin therapy be avoided?

Design

A Markov decision model was used to evaluate the risks and benefits of statin therapy in patients with prior ICH.

Main outcome measure

Life expectancy, measured as quality-adjusted life-years

SUBMITTER: Westover MB 

PROVIDER: S-EPMC3158138 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature