Assessment of intrapartum antibiotic prophylaxis for the prevention of early-onset group B Streptococcal disease.

ABSTRACT:

Background

Most early-onset group B streptococcal (GBS) disease in recent years has occurred in newborns of prenatally GBS-negative mothers who missed intrapartum antibiotic prophylaxis (IAP). We aimed to assess the accuracy of prenatal culture in predicting GBS carriage during labor, the IAP use, and occurrence of early-onset GBS disease.

Methods

We obtained vaginal-rectal swabs at labor for GBS culture from 5497 women of ≥ 32 weeks' gestation and surface cultures at birth from newborns between February 5, 2008 and February 4, 2009 at 3 hospitals in Houston, TX and Oakland, CA. Prenatal cultures were performed by a healthcare provider during routine care, and culture results were obtained from medical records. The accuracy of prenatal culture in predicting intrapartum GBS c

SUBMITTER: Lin FY 

PROVIDER: S-EPMC3158245 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature