Systematic evaluation of genetic variants in three biological pathways on patient survival in low-stage non-small cell lung cancer.

ABSTRACT:

Introduction

Studies from selected candidate genes suggest that single-nucleotide polymorphisms (SNPs) involved in glutathione metabolism, DNA repair, or inflammatory responses may affect overall survival (OS) in stages I to II or low-stage non-small cell lung cancer (LS-NSCLC); however, results are inconclusive. In this study, we took a systematic pathway-based approach to simultaneously evaluate the impact of genetic variation from these three pathways on OS after LS-NSCLC diagnosis.

Methods

DNA from 647 patients with LS-NSCLC was genotyped for 480 SNPs (tag-SNPs) tagging 57 genes from the three candidate pathways. Associations of tag-SNPs with OS were assessed at the individual SNP and whole gene levels, adjusting for age, tumor stage, surgery type, and adjuvant therapy.

SUBMITTER: Pankratz VS 

PROVIDER: S-EPMC3158278 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature