Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol.

ABSTRACT:

Objective

We sought to determine the association between time to initial antibiotics and mortality of patients with septic shock treated with an emergency department-based early resuscitation protocol.

Design

Preplanned analysis of a multicenter randomized controlled trial of early sepsis resuscitation.

Setting

Three urban U.S. emergency departments.

Patients

Adult patients with septic shock.

Interventions

A quantitative resuscitation protocol in the emergency department targeting three physiological variables: central venous pressure, mean arterial pressure, and either central venous oxygen saturation or lactate clearance. The study protocol was continued until all end points were achieved or a maximum of 6 hrs.

Measurements and main results

Data

SUBMITTER: Puskarich MA 

PROVIDER: S-EPMC3158284 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature