Influence of irritable bowel syndrome on treatment outcome in gastroesophageal reflux disease.

ABSTRACT:

Aim

To investigate the influence of irritable bowel syndrome (IBS)-like symptoms on treatment outcomes with pantoprazole in gastroesophageal reflux disease (GERD) in a real life setting.

Methods

For this prospective, open-label, multinational, multicentre study, 1888 patients assessed by the investigators as suffering from GERD were recruited. The patients were additionally classified as with or without IBS-like symptoms at baseline. They were treated with pantoprazole 40 mg once daily and completed the Reflux Questionnaire™ (ReQuest™) short version daily. Response rates and symptom scores were compared after 4 and 8 wk of treatment for subgroups defined by the subclasses of GERD [erosive (ERD) and non-erosive reflux disease (NERD)] and the presence of IBS-like symptoms.

SUBMITTER: Monnikes H 

PROVIDER: S-EPMC3158400 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature