Multistage Tandem Mass Spectrometry of Chondroitin Sulfate and Dermatan Sulfate.

ABSTRACT: Chondroitin/dermatan sulfate (CS/DS) is a glycosaminoglycan (GAG) found in abundance in extracellular matrices. In connective tissue, CS/DS proteoglycans play structural roles in maintaining viscoelasticity through the large number of immobilized sulfate groups on CS/DS chains. CS/DS chains also bind protein families including growth factors and growth factor receptors. Through such interactions, CS/DS chains play important roles in neurobiochemical processes, connective tissue homeostasis, coagulation, and cell growth regulation. Expression of DS has been observed to increase in cancerous tissue relative to controls. In earlier studies, MS(2) was used to compare the types of CS/DS isomers present in biological samples. The results demonstrated that product ion abundances reflect the types

SUBMITTER: Bielik AM 

PROVIDER: S-EPMC3158619 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature