Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury.

ABSTRACT: Ischemia/reperfusion (I/R) injury in the kidney is a major cause of acute kidney injury (AKI) in humans and is associated with significantly high mortality. To identify genes that modulate kidney injury and repair, we conducted genome-wide expression analysis in the rat kidneys after I/R and found that the mRNA levels of fibrinogen (Fg)α, Fgβ, and Fgγ chains significantly increase in the kidney and remain elevated throughout the regeneration process. Cellular characterization of Fgα and Fgγ chain immunoreactive proteins shows a predominant expression in renal tubular cells and the localization of immunoreactive Fgβ chain protein is primarily in the renal interstitium in healthy and regenerating kidney. We also show that urinary excretion of Fg is massively increased after kidney damage and

SUBMITTER: Krishnamoorthy A 

PROVIDER: S-EPMC3158721 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature