Dose response between physical activity and risk of coronary heart disease: a meta-analysis.

ABSTRACT:

Background

No reviews have quantified the specific amounts of physical activity required for lower risks of coronary heart disease when assessing the dose-response relation. Instead, previous reviews have used qualitative estimates such as low, moderate, and high physical activity.

Methods and results

We performed an aggregate data meta-analysis of epidemiological studies investigating physical activity and primary prevention of CHD. We included prospective cohort studies published in English since 1995. After reviewing 3194 abstracts, we included 33 studies. We used random-effects generalized least squares spline models for trend estimation to derive pooled dose-response estimates. Among the 33 studies, 9 allowed quantitative estimates of leisure-time physical activity. Ind

SUBMITTER: Sattelmair J 

PROVIDER: S-EPMC3158733 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature