Neuroinflammation induces glial aromatase expression in the uninjured songbird brain.

ABSTRACT:

Background

Estrogens from peripheral sources as well as central aromatization are neuroprotective in the vertebrate brain. Under normal conditions, aromatase is only expressed in neurons, however following anoxic/ischemic or mechanical brain injury; aromatase is also found in astroglia. This increased glial aromatization and the consequent estrogen synthesis is neuroprotective and may promote neuronal survival and repair. While the effects of estradiol on neuroprotection are well studied, what induces glial aromatase expression remains unknown.

Methods

Adult male zebra finches (Taeniopygia guttata) were given a penetrating injury to the entopallium. At several timepoints later, expression of aromatase, IL-1β-like, and IL-6-like were examined using immunohistochemistry. A sec

SUBMITTER: Duncan KA 

PROVIDER: S-EPMC3158750 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature