Lymphoid organ-resident dendritic cells exhibit unique transcriptional fingerprints based on subset and site.

ABSTRACT: Lymphoid organ-resident DC subsets are thought to play unique roles in determining the fate of T cell responses. Recent studies focusing on a single lymphoid organ identified molecular pathways that are differentially operative in each DC subset and led to the assumption that a given DC subset would more or less exhibit the same genomic and functional profiles throughout the body. Whether the local milieu in different anatomical sites can also influence the transcriptome of DC subsets has remained largely unexplored. Here, we interrogated the transcriptional relationships between lymphoid organ-resident DC subsets from spleen, gut- and skin-draining lymph nodes, and thymus of C57BL/6 mice. For this purpose, major resident DC subsets including CD4 and CD8 DCs were sorted at high purity and

SUBMITTER: Elpek KG 

PROVIDER: S-EPMC3158776 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature