Perivascular T-cell infiltration leads to sustained pulmonary artery remodeling after endothelial cell damage.

ABSTRACT: Pulmonary hypertension is a vascular proliferative disease characterized by pulmonary artery remodeling because of dysregulated endothelial and smooth muscle cell proliferation. Although the role of inflammation in the development of the disease is not well-defined, plexogenic lesions in human disease are characterized by perivascular inflammation composed, in part, of T cells. We explored the role of T-cell infiltration on pulmonary vascular remodeling after endothelial cell damage. We induced endothelial cell damage using monocrotaline and isolated the role of T cells by using Rag1(tm1Mom) mice and performing adoptive T-cell transfer. We found that monocrotaline causes pulmonary vascular endothelial cell injury followed by a perivascular inflammatory response. The infiltration of inflamm

SUBMITTER: Cuttica MJ 

PROVIDER: S-EPMC3159087 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature