Neural crest cell origin and signals for intrinsic neurogenesis in the mammalian respiratory tract.

ABSTRACT: Our study investigates the innervation of the respiratory tract during mouse embryonic development, with a focus on the identification of cell origin and essential developmental signals for the resident, or intrinsic, neurons. Using lineage tracing, we show that these intrinsic neurons are exclusively derived from neural crest cells, and cluster to form ganglia that reside in the dorsal trachea and medial bronchi with diminishing frequency. Comparisons of intrinsic neurogenesis between wild-type, glial cell-derived neurotrophic factor (GDNF)(-/-), neurturin(-/-), and tyrosine kinase receptor Ret(-/-) embryos, in combination with lung organ cultures, identified that Ret signaling, redundantly activated by GDNF family members, is required for intrinsic neurogenesis in the trachea and primary

SUBMITTER: Langsdorf A 

PROVIDER: S-EPMC3159091 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature