Steric Crowding Makes Challenging C(sp3)-F Reductive Eliminations Feasible.

ABSTRACT: A high-yielding fluorination of (triphos)Pt-R(+) has been achieved using an array of F(+) sources, with XeF(2) yielding R-F in minutes. The C-F coupling proved to be a stereoretentive process that proceeds via a concerted reductive elimination from a putative dicationic Pt(IV) center. The larger the steric congestion of the (triphos)Pt-C(sp3) (+) complexes, the more efficient the fluorination, seemingly a result of sterically accelerated C-F reductive elimination along with simultaneous deceleration of its competing processes (β-H elimination).

SUBMITTER: Zhao SB 

PROVIDER: S-EPMC3159157 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature