CD4 cell responses to combination antiretroviral therapy in patients starting therapy at high CD4 cell counts.

ABSTRACT:

Objective

To examine CD4 cell responses to combination antiretroviral therapy (cART) in patients enrolled in the Australian HIV Observational Database who commenced cART at CD4 cell counts >350 cells per microliter.

Methods

CD4 cell counts were modelled using random effects, repeated measurement models in 432 HIV-infected adults from Australian HIV Observational Database who commenced their first cART regimen and had a baseline CD4 count >350 cells per microliter. Using published AIDS and/or death incidence rates combined with the data summarized by time and predicted CD4 cell count, we calculated the expected reduction in risk of an event for different starting baseline CD4 strata.

Results

Mean CD4 counts increased above 500 cells per microliter in all baseline CD4 s

SUBMITTER: Wright ST 

PROVIDER: S-EPMC3159689 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature