Presurgical serum cystatin C and risk of acute kidney injury after cardiac surgery.

ABSTRACT:

Background

Acute kidney injury (AKI) after cardiac surgery is associated with poor outcomes, but is challenging to predict from information available before surgery.

Study design

Prospective cohort study.

Setting & participants

The TRIBE-AKI (Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury) Consortium enrolled 1,147 adults undergoing cardiac surgery at 6 hospitals from 2007-2009; participants were selected for high AKI risk.

Predictors

Presurgical values for cystatin C, creatinine, and creatinine-based estimated glomerular filtration rate (eGFR) were categorized into quintiles and grouped as "best" (quintiles 1-2), "intermediate" (quintiles 3-4), and "worst" (quintile 5) kidney function.

Outcomes

The primary outcome was AK

SUBMITTER: Shlipak MG 

PROVIDER: S-EPMC3159705 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature