Delta Protocadherin 10 is Regulated by Activity in the Mouse Main Olfactory System.

ABSTRACT: Olfactory sensory neurons (OSNs) are thought to use activity-dependent and independent mechanisms to regulate the expression of axon guidance genes. However, defining the molecular mechanisms that underlie activity-dependent OSN guidance has remained elusive. Only a handful of genes have been identified whose expression is regulated by activity. Interestingly, all of these genes have been shown to play a role in OSN axon guidance, underscoring the importance of identifying other genes regulated by activity. Furthermore, studies suggest that more than one downstream mechanism regulates target gene expression. Thus, both the number of genes regulated by activity and how many total mechanisms control this expression are not well understood. Here we identify delta protocadherin 10 (pcdh10) as

SUBMITTER: Williams EO 

PROVIDER: S-EPMC3159872 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature