Optimal regulatory strategies for metabolic pathways in Escherichia coli depending on protein costs.

ABSTRACT: While previous studies have shed light on the link between the structure of metabolism and its transcriptional regulation, the extent to which transcriptional regulation controls metabolism has not yet been fully explored. In this work, we address this problem by integrating a large number of experimental data sets with a model of the metabolism of Escherichia coli. Using a combination of computational tools including the concept of elementary flux patterns, methods from network inference and dynamic optimization, we find that transcriptional regulation of pathways reflects the protein investment into these pathways. While pathways that are associated to a high protein cost are controlled by fine-tuned transcriptional programs, pathways that only require a small protein cost are transcript

SUBMITTER: Wessely F 

PROVIDER: S-EPMC3159982 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature