Chiral sulfinamide/achiral sulfonic acid cocatalyzed enantioselective protonation of enol silanes.

ABSTRACT: The application of chiral sulfinamides and achiral sulfonic acids as a cocatalyst system for enantioselective protonation reactions is described. Structurally simple, easily accessible sulfinamides were found to induce moderate-to-high ee's in the formation of 2-aryl-substituted cycloalkanones from the corresponding trimethylsilyl enol ethers.

SUBMITTER: Beck EM 

PROVIDER: S-EPMC3160112 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature