TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis.

ABSTRACT: Mammalian epidermis consists of the interfollicular epidermis, hair follicles (HFs) and associated sebaceous glands (SGs). It is constantly renewed by stem and progenitor cell populations that have been identified and each compartment features a distinct mechanism of cellular turnover during renewal. The functional relationship between the diverse stem cell (SC) pools is not known and molecular signals regulating the establishment and maintenance of SC compartments are not well understood. Here, we performed lineage tracing experiments to demonstrate that progeny of HF bulge SCs transit through other SC compartments, suggesting a hierarchy of competent multipotent keratinocytes contributing to tissue renewal. The bulge was identified as a bipotent SC compartment that drives both cyclic reg

SUBMITTER: Petersson M 

PROVIDER: S-EPMC3160179 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature