The impact of substance use on brain structure in people at high risk of developing schizophrenia.

ABSTRACT: Ventricular enlargement and reduced prefrontal volume are consistent findings in schizophrenia. Both are present in first episode subjects and may be detectable before the onset of clinical disorder. Substance misuse is more common in people with schizophrenia and is associated with similar brain abnormalities. We employ a prospective cohort study with nested case control comparison design to investigate the association between substance misuse, brain abnormality, and subsequent schizophrenia. Substance misuse history, imaging data, and clinical information were collected on 147 subjects at high risk of schizophrenia and 36 controls. Regions exhibiting a significant relationship between level of use of alcohol, cannabis or tobacco, and structure volume were identified. Multivariate regress

SUBMITTER: Welch KA 

PROVIDER: S-EPMC3160229 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature