Establishment of an immortalized human endometrial stromal cell line with functional responses to ovarian stimuli.

ABSTRACT: Studies on the mechanisms of decidualization and endometriosis are often hampered by lack of primary endometrial cells. To facilitate in vitro studies, we established a human endometrial stromal cell line, KC02-44D, immortalized with human telomerase reverse transcriptase. Upon exposure to ovarian stimuli, KC02-44D cells showed similar cytoskeletal marker or gene expression and biochemical phenotype to primary endometrial stromal cells. KC02-44D would be useful for studies of human endometrial function and its associated pathologies.

SUBMITTER: Yuhki M 

PROVIDER: S-EPMC3160358 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature