Multidrug-resistance proteins are weak tumor associated antigens for colorectal carcinoma.

ABSTRACT:

Background

Multidrug resistance (MDR) is a clinically, highly relevant phenomenon. Under chemotherapy many tumors show an increasing resistance towards the applied substance(s) and to a certain extent also towards other agents. An important molecular cause of this phenomenon is an increased expression of transporter proteins. The functional relationship between high expression levels and chemotherapy resistance makes these MDR and MRP (MDR related protein) proteins to interesting therapeutic targets. We here wanted to systematically analyze, whether these proteins are tumor specific antigens which could be targeted immunologically.

Results

Using the reverse immunology approach, 30 HLA-A2.1 restricted MDR and MRP derived peptides (MDP) were selected. Stimulated T cell lines g

SUBMITTER: Mullins CS 

PROVIDER: S-EPMC3160416 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature