The differential disease regulome.

ABSTRACT:

Background

Transcription factors in disease-relevant pathways represent potential drug targets, by impacting a distinct set of pathways that may be modulated through gene regulation. The influence of transcription factors is typically studied on a per disease basis, and no current resources provide a global overview of the relations between transcription factors and disease. Furthermore, existing pipelines for related large-scale analysis are tailored for particular sources of input data, and there is a need for generic methodology for integrating complementary sources of genomic information.

Results

We here present a large-scale analysis of multiple diseases versus multiple transcription factors, with a global map of over-and under-representation of 446 transcription factor

SUBMITTER: Sandve GK 

PROVIDER: S-EPMC3160420 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature