Multipotent progenitor cells derived from adult peripheral blood of swine have high neurogenic potential in vitro.

ABSTRACT: Peripheral blood-derived multipotent adult progenitor cells (PBD-MAPCs) are a novel population of stem cells, isolated from venous blood of green fluorescent protein transgenic swine, which proliferate as multicellular non-adherent spheroids. Using a simple differentiation protocol, a large proportion of these cells developed one of five distinct neural cell phenotypes, indicating that these primordial cells have high neurogenic potential. Cells exhibiting neural morphologies developed within 48 h of exposure to differentiation conditions, increased in percentage over 2 weeks, and stably maintained the neural phenotype for three additional weeks in the absence of neurogenic signaling molecules. Cells exhibited dynamic neural-like behaviors including extension and retraction of processes wi

SUBMITTER: Spitzer N 

PROVIDER: S-EPMC3160519 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature