Identification of novel biomarkers in seasonal allergic rhinitis by combining proteomic, multivariate and pathway analysis.

ABSTRACT:

Background

Glucocorticoids (GCs) play a key role in the treatment of seasonal allergic rhinitis (SAR). However, some patients show a low response to GC treatment. We hypothesized that proteins that correlated to discrimination between symptomatic high and low responders (HR and LR) to GC treatment might be regulated by GCs and therefore suitable as biomarkers for GC treatment.

Methodology/principal findings

We identified 953 nasal fluid proteins in symptomatic HR and LR with a LC MS/MS based-quantitative proteomics analysis and performed multivariate analysis to identify a combination of proteins that best separated symptomatic HR and LR. Pathway analysis showed that those proteins were most enriched in the acute phase response pathway. We prioritized candidate biomarkers fo

SUBMITTER: Wang H 

PROVIDER: S-EPMC3160968 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature