Characterisation of five candidate genes within the ETEC F4ab/ac candidate region in pigs.

ABSTRACT:

Background

Enterotoxigenic Escherichia coli (ETEC) that express the F4ab and F4ac fimbriae is a major contributor to diarrhoea outbreaks in the pig breeding industry, infecting both newborn and weaned piglets. Some pigs are resistant to this infection, and susceptibility is inherited as a simple dominant Mendelian trait. Indentifying the genetics behind this trait will greatly benefit pig welfare as well as the pig breeding industry by providing an opportunity to select against genetically susceptible animals, thereby reducing the number of diarrhoea outbreaks. The trait has recently been mapped by haplotype sharing to a 2.5 Mb region on pig chromosome 13, a region containing 18 annotated genes.

Findings

The coding regions of five candidate genes for susceptibility to ETEC F

SUBMITTER: Jacobsen M 

PROVIDER: S-EPMC3160978 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature