Comparative analysis of methods for detecting interacting loci.

ABSTRACT:

Background

Interactions among genetic loci are believed to play an important role in disease risk. While many methods have been proposed for detecting such interactions, their relative performance remains largely unclear, mainly because different data sources, detection performance criteria, and experimental protocols were used in the papers introducing these methods and in subsequent studies. Moreover, there have been very few studies strictly focused on comparison of existing methods. Given the importance of detecting gene-gene and gene-environment interactions, a rigorous, comprehensive comparison of performance and limitations of available interaction detection methods is warranted.

Results

We report a comparison of eight representative methods, of which seven were speci

SUBMITTER: Chen L 

PROVIDER: S-EPMC3161015 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature