Diagnostic value of circulating tumor cell detection in bladder and urothelial cancer: systematic review and meta-analysis.

ABSTRACT:

Background

The diagnostic value and prognostic significance of circulating tumor cell (CTC) detection in patients with bladder cancer is controversial. We performed a meta-analysis to consolidate current evidence regarding the use of CTC detection assays to diagnose bladder and other urothelial cancers and the association of CTC positivity with advanced, remote disease.

Methods

Studies that investigated the presence of CTCs in the peripheral blood of patients with bladder cancer and/or urothelial cancer were identified and reviewed. Sensitivities, specificities, and positive (LR+) and negative likelihood ratios (LR-) of CTC detection in individual studies were calculated and meta-analyzed by random effects model. Overall odds ratio of CTC positivity in patients with advanced

SUBMITTER: Msaouel P 

PROVIDER: S-EPMC3161042 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature