Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database.

ABSTRACT:

Background

Structural studies are increasingly providing huge amounts of information on multi-protein assemblies. Although a complete understanding of cellular processes will be dependent on an explicit characterization of the intermolecular interactions that underlie these assemblies and mediate molecular recognition, these are not well described by standard representations.

Results

Here we present PICCOLO, a comprehensive relational database capturing the details of structurally characterized protein-protein interactions. Interactions are described at the level of interacting pairs of atoms, residues and polypeptide chains, with the physico-chemical nature of the interactions being characterized. Distance and angle terms are used to distinguish 12 different interaction typ

SUBMITTER: Bickerton GR 

PROVIDER: S-EPMC3161047 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature