Early second-trimester serum miRNA profiling predicts gestational diabetes mellitus.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM) is one type of diabetes that presents during pregnancy and significantly increases the risk of a number of adverse consequences for the fetus and mother. The microRNAs (miRNA) have recently been demonstrated to abundantly and stably exist in serum and to be potentially disease-specific. However, no reported study investigates the associations between serum miRNA and GDM.

Methodology/principal findings

We systematically used the TaqMan Low Density Array followed by individual quantitative reverse transcription polymerase chain reaction assays to screen miRNAs in serum collected at 16-19 gestational weeks. The expression levels of three miRNAs (miR-132, miR-29a and miR-222) were significantly decreased in GDM women with respect to

SUBMITTER: Zhao C 

PROVIDER: S-EPMC3161072 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature