Standardized preoperative corticosteroid treatment in neonates undergoing cardiac surgery: results from a randomized trial.

ABSTRACT:

Objective

A heightened inflammatory response occurs after cardiac surgery. The perioperative use of glucocorticoids has been advocated as a method to improve postoperative outcomes. Randomized prospective studies to quantify the effect of methylprednisolone on perioperative outcomes in neonatal cardiac surgery have not been performed. We sought to determine whether preoperative methylprednisolone would improve postoperative recovery in neonates requiring cardiac surgery.

Methods

Neonates scheduled for cardiac surgery were randomly assigned to receive either 2-dose (8 hours preoperatively and operatively, n = 39) or single-dose (operatively, n = 37) methylprednisolone (30 mg/kg per dose) in a prospective double-blind trial. The primary outcome was the incidence of low cardiac

SUBMITTER: Graham EM 

PROVIDER: S-EPMC3161127 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature