Hypothalamic actions and interactions of alcohol and IGF-1 on the expression of glial receptor protein tyrosine phosphatase-β during female pubertal development.

ABSTRACT:

Background

Hypothalamic glial-neuronal communications are important for the activation of luteinizing hormone releasing hormone (LHRH) secretion at the time of puberty. As we have shown that alcohol (ALC) diminishes prepubertal LHRH secretion and delays puberty, we first assessed the effects of short-term ALC administration on the basal expression of a specific gene family involved in glial-neuronal communications. Second, as insulin-like growth factor-1 (IGF-1) is a critical regulator of LHRH secretion and the pubertal process, we then assessed whether IGF-1 could induce the expression of these signaling genes and determine whether ALC can block this affect.

Methods

Immature female rats were fed a liquid diet containing ALC for 6 days beginning when 27 days old. Control ani

SUBMITTER: Srivastava VK 

PROVIDER: S-EPMC3161137 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature