Coregulation mapping based on individual phenotypic variation in response to virus infection.

ABSTRACT:

Background

Gene coregulation across a population is an important aspect of the considerable variability of the human immune response to virus infection. Methodology to investigate it must rely on a number of ingredients ranging from gene clustering to transcription factor enrichment analysis.

Results

We have developed a methodology to investigate the gene to gene correlations for the expression of 34 genes linked to the immune response of Newcastle Disease Virus (NDV) infected conventional dendritic cells (DCs) from 145 human donors. The levels of gene expression showed a large variation across individuals. We generated a map of gene co-expression using pairwise correlation and multidimensional scaling (MDS). The analysis of these data showed that among the 13 genes left aft

SUBMITTER: Nudelman G 

PROVIDER: S-EPMC3161383 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature