TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway.

ABSTRACT:

Background

Even though thymic stromal lymphopoietin (TSLP) has been implicated in the development of allergic inflammation, its influence on immune tolerance mediated by regulatory T cells (Treg) have not been explored. We aimed to dissect the influence of TSLP on immunosuppressive activities of Treg and its potential consequences in human allergic asthma.

Methods

In vitro culture system was utilized to study the effects of TSLP on human Treg. The functional competency of pulmonary Treg from a cohort of 15 allergic asthmatic, 15 healthy control, and 15 non-allergic asthmatic subjects was also evaluated by suppression assays and flow cytometric analysis.

Results

Activated pulmonary Treg expressed TSLP-R and responded to TSLP-mediated activation of STAT5. TSLP directly

SUBMITTER: Nguyen KD 

PROVIDER: S-EPMC3161393 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature