Cytoskeletal actin networks in motile cells are critically self-organized systems synchronized by mechanical interactions.

ABSTRACT: Growing networks of actin fibers are able to organize into compact, stiff two-dimensional structures inside lamellipodia of crawling cells. We put forward the hypothesis that the growing actin network is a critically self-organized system, in which long-range mechanical stresses arising from the interaction with the plasma membrane provide the selective pressure leading to organization. We show that a simple model based only on this principle reproduces the stochastic nature of lamellipodia protrusion (growth periods alternating with fast retractions) and several of the features observed in experiments: a growth velocity initially insensitive to the external force; the capability of the network to organize its orientation; a load-history-dependent growth velocity. Our model predicts that t

SUBMITTER: Cardamone L 

PROVIDER: S-EPMC3161604 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature