Antipsychotic drugs and heart muscle disorder in international pharmacovigilance: data mining study.

ABSTRACT:

Objectives

To examine the relation between antipsychotic drugs and myocarditis and cardiomyopathy.

Design

Data mining using bayesian statistics implemented in a neural network architecture.

Setting

International database on adverse drug reactions run by the World Health Organization programme for international drug monitoring.

Main outcome measures

Reports mentioning antipsychotic drugs, cardiomyopathy, or myocarditis.

Results

A strong signal existed for an association between clozapine and cardiomyopathy and myocarditis. An association was also seen with other antipsychotics as a group. The association was based on sufficient cases with adequate documentation and apparent lack of confounding to constitute a signal. Associations between myocarditis or ca

SUBMITTER: Coulter DM 

PROVIDER: S-EPMC31617 | biostudies-literature | 2001 May

REPOSITORIES: biostudies-literature